p120 Catenin-Mediated Stabilization of E-Cadherin Is Essential for Primitive Endoderm Specification.
E-cadherin-mediated cell-cell adhesion is critical for naive pluripotency of cultured mouse embryonic stem cells (mESCs).E-cadherin-depleted mESC fail to downregulate their pluripotency program and are unable to initiate lineage commitment.To further explore the roles of cell adhesion molecules during mESC differentiation, we focused on p120 cateni